# Trick to get Iss plots as nullclines in v-iapp plane # Conductances in pS; currents in fA; Ca concentrations in uM # Frozen variables: par s=1.0, lambda=1.0, c=0.1, cer=10 # Ik par gk=2700.0, vn=-16, sn=5.6, vk=-75, # Is par gs=200, vs=-52, ss=5 # Ikatp par gkatp=120.0 # Ica par gca=1000, vca=25, vm=-20, sm=12 # Ikca par gkca=0.0, kd=0.6, nh=5 # Icrac par vcrac=-30.0, cerbar=4.0, gcracbar=0.0, sloper=1 # Miscellaneous par cm=5300 # Functions ninf(v) = 1/(1+exp((vn-v)/sn)) minf(v) = 1/(1+exp((vm-v)/sm)) sinf(v) = 1/(1+exp((vs-v)/ss)) ica(v) = gca*minf(v)*(v-vca) ikca(v,c) = gkca/(1+(kd/c)^nh)*(v-vk) ikatp(v) = gkatp*(v-vk) icrac(v) = gcrac*(v-vcrac) ik(v) = gk*ninf(v)*(v-vk) is(v,s) = gs*s*(v-vk) # Expressions gcrac = gcracbar/(1.0+exp((cer-cerbar)/sloper)) # Equations v' = (-ica(v) - ik(v) - is(v,s) - ikatp(v) - ikca(v, c) - icrac(v) + iapp)/cm iapp' = -iapp @ xlo=-120, xhi=-20, ylo=-7500, yhi=7500 @ xp=v, yp=iapp done